Laboratories

The maintenance of genome stability is an essential task that ensures proper cell function. Under stressful conditions, it becomes crucial for survival. Our research uses budding yeast as an experimental (…)

We are interested in processes that affect DNA stability by regulating DNA damage tolerance pathways via translesion synthesis (TLS), with a special focus on TLS DNA polymerases in yeast and (…)

Our lab is interested in gene expression regulation on a translational level in various bacteria. Using Next Generation Sequencing techniques (including ribosome profiling) in combination with molecular biology and biochemical (…)

Our studies focus on identifying cellular functions of isoprenoids and the regulatory mechanisms that govern their biosynthesis. We seek to elucidate the biochemical pathways that lead to the formation of (…)

Seed dormancy reflects the ability of plants not to germinate despite favorable conditions. Seed dormancy is a fascinating seed property that underlies seed-plant ecological success and forms the overall basis (…)

Our laboratory is interested in mechanisms that control the quality, quantity, and processing of RNAs that originate from expression of the mitochondrial and nuclear genomes in humans. Our main goal (…)

Our laboratory is interested in identifying cellular mechanisms and pharmacological interventions that contribute to the maintenance of protein homeostasis during acute cellular stress and aging. (…)

Regulation of mRNA transcription and co-transcriptional events along with degradation are key for adjusting gene expression in response to stimuli. One line of our research aims to describe regulation of (…)

A new proteostasis mechanism for the removal of protein aggregates and damaged mitochondria has recently been described. Within this process, cellular waste material is ejected from the cell via large (…)

We are interested in understanding how the biophysics of transcription affects gene regulation. Our goal is to apply this knowledge to problems such as SARS-CoV-2 transcription and RNA polymerase III‑related (…)

The Laboratory of Metalloprotein Biology studies the structure and function of metalloproteins and metalloenzymes. We aim to understand how microorganisms acquire, handle, use and detoxify essential metal ions. We are (…)

We are interested in understanding the interactions of pathogenic microorganisms with their human host. We explore the molecular details of how cell-intrinsic and cytokine-enhanced immunity protects the interior of the (…)