Research projects

NATIONAL SCIENCE CENTRE

HARMONIA
1. Title:  Mechanisms of ribonucleotides incorporation and repair in E.coli cells.
Project leader: Dr Karolina Makieła-Dzbeńska
Duration: 2016-04-12 / 2021-04-11
Budget: 549 360 PLN
2. Title: The CMGE helicase-polimerase complex a factor integrating the regulation of cell cyle progression and DNA replication
Project leader: Dr Michał Dmowski
Duration: 2018-05-18 / 2021-05-17
Budget: 1 288 000 PLN
3. Title: The platform based on nanobody (VHH) against SWI/SNF-type chromatin remodeling complex subunits as the innovative tool for precisely controlled complex innactivation and molecular biology studies..
Project leader: Dr hab. Tomasz Sarnowski
Duration: 2019-07-26 / 2022-07-25
Budget: 1 499 400 PLN

MINIATURA
1. Title: Analiza funkcjonalna białek z domeną AAA_25 pod katem ich udziału w procesie replikacji bakteriofagów Lactococcus lactis wyizolowanych z zaburzonych procesów fermentacyjnych
Project leader: Dr Agnieszka Szczepankowska
Duration 2019-11-08 / 2020-11-07
Budget: 48 565 PLN
2. Title: The significance of microRNA-type molecules, UpRoi 1 and UpRoi 2, in the regulation of metabolism of Escherichia coli bacterial cells infected with Φ24B bacteriophage..
Project leader: Dr Sylwia Bloch
Duration: 2020-12-04 / 2021-12-03
Budget: 49 885 PLN
3. Title: Relationships between LSU1 protein and the selective autophagy receptor NBR1 in Arabidopsis thaliana
Project leader: Dr inż. Marcin Olszak
Duration: 2020-12-04 / 2021-12-03
Budget: 49 500 PLN
4.Title: The impact of tRNA levels manipulation on the ribosomes heterogeneity.
Project leader: Dr ABU MUSA MD TALIMUR REZA
Duration: 2020-12-04 / 2021-12-03
Budget: 49 940 PLN

OPUS
1. Title: Search form molecular mechanism of annexin-mediated chloroplast protection against high light stress in Arabidopsis thaliana
Project leader: Dr hab. Dorota Konopka-Postupolska
Duration: 2016-08-17 / 2021-08-16
Budget: 1 213 200 PLN
2. Title:  Changes in transcriptomic and proteomic profiles and life history parameters of Daphnia in the response to alkylating agents contaminating environment.
Project leader: Prof. dr hab. Elżbieta Grzesiuk
Duration: 2017-01-12 / 221-02-11
Budget: 1 059 740 PLN
3. Title: Badanie roli i biosyntezy poliprenoli typu bakteryjnego w komórkach eukariotycznych.
Project leader: Dr Liliana Surmacz
Duration: 2017.01.24 / 2022.01.23
Budget: 900 000 PLN
4. Title:  New functional links in eukaryotic cell: Vesicular trafficking is a genome stability guardian..
Project leader: Dr hab. Adrianna Skoneczna
Duration: 2017-03-07 / 2021-03-06
Budget: 1 069 400 PLN
5. Title:  Interplay of posttranslational redox cysteine modifications and metal ion binding as key to conformational and functional plasticity of innate immunity and cancer biomarkers – S100A8 and S100A9 proteins.
Project leader: Dr Aleksandra Wysłouch-Cieszyńska
Duration: 2016-03-01 / 2021.09.01
Budget: 1 033 600 PLN
6. Title:  Role of small peptides in copper transport in human organism – interactions with albumin.
Project leader: Prof. dr hab. Wojciech Bal
Duration: 2017-07-18 / 2021-07-17
Budget: 1 561 000 PLN
7. Tytuł projektu:  Understanding of the functioning of mitochondrial ATP synthase by studying in yeast the phenotype of human pathology related mutations in the mitochondrial DNA.
Project leader: Dr hab. Róża Kucharczyk
Duration: 2017-07-25 / 2021-07-04
Budget: 1 061 800 PLN
8. Title:  The role of SnRK2 kinases in regulation of pre-mRNA alternative splicing and miRNA biogenesis in plants response to salinity.
Project leader: Prof. dr hab. Grażyna Dobrowolska
Duration: 2017-09-28 / 2021-09-27
Budget: 1 631 250 PLN
9. Title: Molecular mechanisms of splicing dependent transcription elongation check point..
Project leader: Dr hab. Szymon Świeżewski
Duration: 2017-09-29 / 2020-09-28
Budget: 1 520 900 PLN
10. Title: How activation of the Mec1/Tel1 kinase (human ATR/ATM) pathway in response to the nuclear genome damage influences the stability of mitochindrial genome: a study on the yeast model of mutations in polymerase POLG.
Project leader: Dr hab. Aneta Kaniak-Golik
Duration: 2018-01-09 / 2021-01-08
Budget: 818 000 PLN
11. Title: The role of Rbs1 protein in control of general response to defect in tRNA biosynthesis in yeast Saccharomyces cerevisiae
Project leader: Prof. dr hab. Magdalena Rakowska-Boguta
Duration: 2018-01-10 / 2021-01-09
Budget: 957 600 PLN
12. Title: Thermodynamics of halogen bonding in the bio-molecular cage
Project leader: Prof. dr hab. Jarosław Poznański
Duration: 2018-01-15 / 2021-01-14
Budget: 1 398 000 PLN
13. Title: Role of a protein kinase-like effector HopBF1 in virulence of bacterial pathogens..
Project leader: Dr hab. Magdalena Krzymowska
Duration: 2018-01-10 / 2021-01-09
Budget: 1 767 400 PLN
14. Title: Analysis of selected processes influencing the architecture of fungal genomes and proteomes.
Project leader: Dr hab. Anna Muszewska
Duration: 2018-01-19 / 2022-01-18
Budget: 403 840 zł
15. Title: The role of ALKBH proteins in obesity and type 2 diabetes development using the pig model
Project leader: Prof. dr hab. Elżbieta Grzesiuk
Duration: 2019-01-19 / 2022-01-17
Budget: 1 240 920 PLN
16. Title: Quantitative assessment of sediment transport from glaciers of South Shetland Islands on the basis of selected remote sensing methods.
Project leader: Dr hab. Robert Bialik
Duration: 2018-07-02 / 2021-07-01
Budget: 898 400 PLN
17. Title: Variability of Antarctic lichen microbiome in a trophic and a spatio-temporal gradient (King George Island, South Shetland Islands)
Project leader: Dr Jakub Grzesiak
Duration: 2018-05-21 / 2021-05-20
Budget: 817 020 PLN
18. Title: Apoptotic machinery: An ancient adaptation to aerobic conditions?Project
Project leader: Dr hab. Szymon Kaczanowski
Duration: 2018-06-29 / 2021-06-28
Budget: 786 200 PLN
19. Title: SnRK2 protein kinases as integrators of environmental signals in the regulation of the senescence in plants.
Project leader: Dr Anna Marta Kulik
Duration: 2018-10-31 / 2021-10-30
Budget: 1 552 100 PLN
20. Title: Isolation of resistance genes to PVY infection, usefull in potato (Solanum tuberosum L) breading and its functional analysis.
Project leader: Prof. dr hab. Jacek Hennig
Duration: 2018-07-20 / 2021-07-19
Budget: 1 457 500 PLN
21. Title: Clonal analysis of Streptococcus pyogenes strains resistant to macrolide antibiotics.
Project leader: Dr Izabela Kern-Zdanowicz
Duration: 2018-08-14 / 2021-08-13
Budget: 1 027 302 PLN
22. Title: Mechanisms protecting from oxidative damage during aging
Project leader: Dr Ulrike Topf
Duration: 2016-09-30 / 2020-11-29
Budget: 1 200 800 PLN
23. Title: Integrating light and osmotic stress signaling- molecular functions of Plastid Movement Impaired 1 protein from Arabidopsis thaliana.
Project leader: Mgr Olga Sztatelman
Duration: 2019-01-14 / 2022-01-13
Budget: 1 242 600 PLN
24. Title: Dolichol – a superlipid essential for the functioning of the eukaryotic cell
Project leader: Prof. dr hab. Ewa Kula-Świeżewska
Duration: 2019-01-14 / 2022-01-13
Budget: 1 997 400 PLN
25. Title: The role and cooperation of AidB dehydrogenase and AlkB dioxygenase in repair of adducts to DNA and RNA bases
Project leader: Dr hab. Agnieszka Maciejewska
Duration: 2019-01-09 / 2022-01-08
Budget: 924 400 PLN
26. Title: Analysis of functional interdependence between organ-specific choice of alternative transcription start site (altTSS) and SWI/SNF dependent chromatin remodeling in Arabidopsis.
Project leader: Dr Szymon Kubala
Duration: 2019-01-14 / 2022-01-13
Budget: 1 618 800 PLN
27. Title: Novel molecular mechanisms in extracellular copper transport
Project leader: Prof. dr hab. Wojciech Bal
Duration: 2019-01-15 / 2022-01-14
Budget: 1 522 000 PLN
28. Title: Characterization of genetic determinants of propionic acid biosynthesis and assessing of their functionality in selected lactic acid bacteria.
Project leader: Dr hab. Tamara Aleksandrzak-Piekarczyk
Duration: 2019-01-09 / 2022-01-08
Budget: 623 000 PLN
29. Title: Topology of Pseudomonas aeruginosa chromosome. The role of partitioning protein ParB.
Project leader: Prof. d hab. Grażyna Jagura-Burdzy
Duration: 2019-02-15 / 2022-02-14
Budget: 2 100 800 PLN
30. Tytuł projektu: A proteomic approach to define interactors of Zika Virus with the host cell nucleolus.
Project leader: Prof. dr hab. Michał Dadlez
Duration: 2019-01-24 / 2022-01-23
Budget: 1 072 126 PLN
31. Title: Regulation of cell death and OXPHOS activity by Fmp40 ampylase in yeast S. cerevisiae.
Project leader: Dr hab. Róża Kucharczyk
Duration: 2019-06-13 / 2022-06-12
Budget: 1 671 600 PLN
32. Title: The role of HopAG1 effector in virulence of plant pathogenic bacteria.
Project leader: Dr Magdalena Górecka
Duration: 2019-06-18 / 2022-06-17
Budget: 1 021 800 PLN
33. Title: Design of photoswitchable dismantlers of biomaterials made of amyloid fibrils.
Project leader: Dr Dorota Niedziałek
Duration: 2019-06-18 / 2022-06-17
Budget: 618 600 PLN
34. Tytuł projektu: Uncovering novel secondary seed dormancy regulators in Arabidopsis
Project leader: Dr Ruslan Yatusewich
Duration: 2019-06-18 / 2022-06-17
Budget: 1 456 400 PLN
35. Title: Characterisation of function and substrate binding of the prefoldin chaperone in physiology and cellular stress.
Project leader: Dr Ulrike Topf
Duration: 2019-10-01 / 2022-09-30
Budget: 1 882 500 PLN
36. Tytuł projektu: Identification of Streptococcus aninosus virulence factors
Project leader: Dr hab. Izabela Kern-Zdanowicz
Duration: 2019-09-02 / 2022-09-01
Budget: 1 005 620 PLN
37. Title: Modification and action of non-coding RNA
Project leader: Dr Jacek Nowak
Duration: 2020-02-05 / 2023-02-04
Budget: 2 063 140 PLN
38. Title: Functional genomic analysis of Staphylococcus aureus Kayvirus genus phages in a search for molecular basis of wide host-range and the strategies of survival with a host population
Project leader: Dr hab. Małgorzata Barbara Łobocka
Duration: 2020-02-06 / 2023-02-05
Budget: 2 249 194 PLN
39. Title: New aspects of negative regulation of RNA polymerase III in yeast Saccharomyces cerevisiae
Project leader: Dr Małgorzata Maria Cieśla
Duration: 2020-09-01 / 2023-08-31
Budget: 1 252 200 PLN
40. Title: Identification and comprehensive classification of peptidases
Project leader: Dr Kamil Steczkiewicz
Duration: 2020-06-25 / 2023-06-24
Budget: 878 400 PLN
41. Title: Novel mechanisms regulating the activity of cis-prenyltransferases in plants.
Project leader: Dr hab. Liliana Surmacz
Duration: 2020-10-02 / 2024-10-01
Budget: 1 969 800 PLN

PRELUDIUM
1. Title: Do microbiota of Antarctic flowering plants rhizosphere increase their resistance?
Project leader: Mgr Anna Znój
Duration: 2017.02.03 / 2021.02.02
Budget: 148 800 PLN
2. Title: The role of the Cdc45 protein in the maintenance of genomic stability in yeast Saccharomyces cerevisiae..
Project leader: Mgr Milena Denkiewicz-Kruk
Duration: 2017-06-02 / 2021-06-01
Budget: 150 000 PLN
3. Title: Promutagenic function of ubiquitin enzyme variant Mms2 in S. cerevisiae cells.
Project leader: Mgr Michał Krawczyk
Duration: 2017.07.12 / 2021-05-11
Budget: 149 900 PLN
4. Tytuł projektu: Identification of nuclear function of Arabidopsis Target of Rapamycin protein
Project leader: Mgr Paweł Ćwiek
Duration: 2018-01-25 / 2021-01-24
Budget: 180 000 PLN
5. Title: Characterization of genetic determinants of the mannose-specific phosphotransferase system (Man-PTS) determining sensitivity to the newly identified subclass IId bacteriocins.
Project leader: Mgr Aleksandra Tymoszewska
Duration: 2019-01-09 / 2021-01-08
Budget: 139 800 PLN
6. Title: Evaluation of the function of the SNF5-type core sibunit of the SWI/SNF complex on Arabidopsis thaliana using new T-DNA insertionan knock-out line
Project leader: Mgr Jarosław Steciuk
Duration: 2019-01-15 / 2022-01-14
Budget: 210 000 PLN
7. Title: The PA2504 protein – a novel player in regulation of exotoxin A production of Pseudomonas aeruginosa?.
Project leader: Mgr Joanna Drabińska
Duration: 2019-01-24 / 2021-01-23
Budget: 138 720 PLN
8. Title: Prohepcidin as a molecular target of cadmium binding.
Project leader: Mgr Dawid Płonka
Duration: 2019-06-13 / 2021-06-12
Budget: 69 600 PLN
9. Title: Investigation of copper homeostasis disturbances in yeast model of rare neurodegenerative diseases associated with VPS13 proteins deficiencies.
Project leader: Mgr inż. Piotr Soczewka
Duration: 2019-06-13 / 2021-06-12
Budget: 112 800 PLN
10. Title: Fundamentals of copper exchange kinetics between model peptides and small molecules
Project leader: Mgr Radosław Kotuniak
Duration: 2019-06-13 / 2021-06-12
Budget: 132 240 PLN
11. Title: Biology and systematics of Antarctic polar lactic acid bacteria strains of the genus Carnobacterium in the light of phenotypic and genetic analyses..
Project leader: Mgr inż. Katarzyna Kosiorek
Duration: 2019-06-21 / 2021-06-20
Budget: 139 980 PLN
12. Title: Identification of group I SnRK2s substrates involved in RNA metabolism and elucidation the role of their phosphorylation
Project leader: Mgr Adrian Kasztelan
Duration: 2020-02-28 / 2023-02-27
Budget: 210 000 PLN
13. Title: Moonlighting role of yeast WASP (Las17) in the nucleolus: possible implications for Wiskott-Aldrich syndrome etiology.
Project leader: Mgr Justyna Antoniuk-Majchrzak
Duration: 2020-02-05 / 2023-02-04
Budget: 203 544 PLN
14. Title: Analysis of Escherichia coli ydiU mutation suppressors and detergent resistant membrane fraction as a way to discover functional relationships of family SelO AMPylases involved in oxidative stress response from bacteria to humans
Project leader: Mgr Monika Karasiewicz-Urbańska
Duration: 2020-06-15 / 2022-06-14
Budget: 139 656 PLN
15. Title: Analysis of bacteriophage P1 lytic functions as a way to discover the mechanisms of wide dissemination of clinical bacterial strains carrying P1 derivatives with genes encoding resistance to new generation beta-lactam antibiotics
Project leader: Mgr Agnieszka Bednarek
Duration: 2020-06-25 / 2023-06-24
Budget: 139 920 PLN
16. Title: Differential activity of ribonucleotide repair on leading and lagging DNA strand and its consequences for the mechanism and fidelity of replication of both DNA strands in Escherichia coli cells
Project leader: Mgr Krystian Łazowski
Duration: 2020-07-28 / 2022-07-27
Budget: 139 920 PLN

PRELUDIUM BIS
Title: High-resolution analysis of data from proton-deuterium exchange experiments monitored by mass spectrometry.
Project leader: Prof. dr hab. Michał Dadlez
Duration: 2020-10-01 / 2024-09-30
Budget: 519 600 PLN

SONATA
1. Title: Rab-dependent vesicular transport and sterol homeostasis- where is the link?
Project leader: Dr Małgorzata Gutkowska-Stronkowska
Duration: 2017.02.07 / 2021.02.06
Budget: 432 800 PLN
2. Title: Mechanisms of polyprenol biosynthesis regulation at transcriptional level.
Project leader: Dr Daniel Buszewicz
Duration: 2018-04-20 / 2021-04-19
Budget: 990 000 PLN
3. Title: Comprehensive study of the role of Rysto, a TIR-NB-LRR class receptor in potato innate immunity
Project leader: Dr Marta Grech-Baran
Duration: 2020-06-25 / 2023-06-24
Budget: 909 000 PLN
4. Title: Molecular mechanisms driving formation of muscular exophers and their role in proteostasis and life cycle of C. elegans
Project leader: Dr Michał Turek
Duration: 2020-11-05 / 2023-11-04
Budget: 1 896 240 PLN

SONATA BIS
1. Title: Dissection of putative transcriptional regulators from Pseudomonas aeruginosa proteome dependent on ParA/ParB using systems biology tools.
Project leader: Dr hab. Aneta Bartosik
Duration: 2016.04.20 / 2021.04.19
Budget: 1 518 680 PLN
2. Title: Analysis of the human SKI complex, a central player in cytoplasmic RNA decay and surveillance pathways
Project leader: Dr hab. Rafał Tomecki
Duration: 2018-05-08 / 2023-05-07
Budget: 2 643 200 PLN
3. Title: Bet-hedging in plants – multi level analysis of seed dormancy variability – from singel cell to population
Project leader: Dr hab. Szymon Świeżewski
Duration: 2019-06-13 / 2024-06-12
Budget: 3 711 000 PLN
4. Title: How does ribosome heterogeneity contribute to cellular stress defense?
Project leader: Dr Ulrike Topf
Duration: 2020-10-01 / 2025-09-30
Budget: 3 861 212 zł

SONATINA
1. Title: Polyhydroxyacids of psychrophilic polar region bacteria: role in bacterial adaptation to stress conditions and biotechnological potential
Project leader: Dr Jakub Grzesiak
Duration: 2017-10-10 / 2021-10-09
Budget: 647 116 PLN
2. Title: Transport pathway for non-coding RNA during meiosis
Project leader: Dr Julita Gruchota
Duration: 2019-09-12 / 2022-09-11
Budget: 999 465 PLN

NATIONAL CENTRE FOR RESEARCH AND DEVELOPMENT

Title: Application of novel diagnostic and therapeutical methods in epilepsy and neurodevelopmental abnormalities in children based on the clinical and cellular model of mTOR dependent epilepsy
Project leader: Prof. dr hab. Michał Dadlez
Duration: 2017-04-01 / 2021-09-30
Budget: 3 928 980 zł

THE POLISH NATIONAL AGENCY FOR ACADEMIC EXCHANGE

POLONIUM
1. Title: Selective autophagy in Arabidopsis thaliana.
Project leader: Prof. dr hab. Agnieszka Sirko
Duration: 2019-01-01 / 2021-12-31
Budget: 20 000 PLN
2. Title: Construction of the yeast strains expressing the Bi-genomic Split-GFP.
Project leader: Dr hab. Róża Kucharczyk
Duration: 2020-01-01 / 2021-12-31
Budget: 14 400 PLN
3. Title: Characterization of alternative isoforms of the shared RNA polymerase I and III subunit, POLR1D in growth and transformation of colorectal cancer.
Project leader: Dr Damian Graczyk
Duration: 2020-01-01 / 2021-12-31
Budget: 8 300 PLN
4. Title: Silver ion interacttion with nuclear receptors: the molecular basis for novel mechanism of silvet toxicity.
Project leader: Prof. dr hab. Wojciech Bal
Duration: 2020-01-01 / 2021-12-31
Budget: 17 100 PLN

POLISH RETURNS
1. Title: Role of satellite repeat transcripts in herpesvirus infection.
Project leader: Dr Maciej Nogalski
Duration: 2021-07-01 / 2025-07-01
Budget: 1 780 000 PLN
2. Title: Identification and characterisation of novel anti-bacterial restriction factors Project leader: Dr Michał Wandel
Duration: 2021-09-01 / 2025-09-01
Budget: 1 780 000 PLN
3. Title: Functional framework for viral RNA-dependent RNA polymerase, a major target in COVID19 treatment.
Project leader: dr Tomasz Turowski
Duration: 2021-08-01 / 2025-07-31
Budget: 1 760 000 PLN