Research projects

NATIONAL SCIENCE CENTRE

HARMONIA

Title: The CMGE helicase-polimerase complex a factor integrating the regulation of cell cyle progression and DNA replication
Project leader: Dr Michał Dmowski
Duration: 2018-05-18 / 2022-05-17
Budget: 1 288 000 PLN
Title: The platform based on nanobody (VHH) against SWI/SNF-type chromatin remodeling complex subunits as the innovative tool for precisely controlled complex innactivation and molecular biology studies
Project leader: Dr hab. Tomasz Sarnowski
Duration: 2019-07-26 / 2022-07-25
Budget: 1 499 400 PLN

MINIATURA

Title: Species diversity of gastrointestinal parasites of the Antarctic fur seal (Arctocephalus gazella)
Project leader: Dr Katarzyna Tołkacz
Duration: 2021-12-15 / 2022-12-14
Budget: 49 995 PLN
Title: Identification of new proteins involved in DNA segregation and condensation in Pseudomonas aeruginosa using transposon insertion sequencing (Tn-seq)
Project leader: Dr Adam Kawałek
Duration: 2021-12-15 / 2022-12-14
Budget: 49 500 PLN
Title: Effects of the selected biochars on dark fermentation: efficiency of hydrogen production from sugar beet molasses and stability of microbial communities in continuous system
Project leader: Dr inż. Anna Detman
Duration: 2021-12-02 / 2022-12-01
Budget: 49 896 PLN

OPUS

Title: Changes in transcriptomic and proteomic profiles and life history parameters of Daphnia in the response to alkylating agents contaminating environment
Project leader: Prof. dr hab. Elżbieta Grzesiuk
Duration: 2017-01-12 / 221-02-11
Budget: 1 059 740 PLN
Title: Study of the role and biosynthesis of bacterial-like polyprenols in eukaryoticyc cells
Project leader: Dr Liliana Surmacz
Duration: 2017-01-24 / 2022-01-23
Budget: 900 000 PLN
Title: Interplay of posttranslational redox cysteine modifications and metal ion binding as key to conformational and functional plasticity of innate immunity and cancer biomarkers – S100A8 and S100A9 proteins
Project leader: Dr Aleksandra Wysłouch-Cieszyńska
Duration: 2016-03-01 / 2022-09-01
Budget: 1 033 600 PLN
Title: Understanding of the functioning of mitochondrial ATP synthase by studying in yeast the phenotype of human pathology related mutations in the mitochondrial DNA.
Project leader: Dr hab. Róża Kucharczyk
Duration: 2017-07-25 / 2022-07-04
Budget: 1 061 800 PLN
Title: The role of SnRK2 kinases in regulation of pre-mRNA alternative splicing and miRNA biogenesis in plants response to salinity
Project leader: Prof. dr hab. Grażyna Dobrowolska
Duration: 2017-09-28 / 2022-09-27
Budget: 1 631 250 PLN
Title: How activation of the Mec1/Tel1 kinase (human ATR/ATM) pathway in response to the nuclear genome damage influences the stability of mitochindrial genome: a study on the yeast model of mutations in polymerase POLG
Project leader: Dr hab. Aneta Kaniak-Golik
Duration: 2018-01-09 / 2023-01-08
Budget: 818 000 PLN
Title: The role of Rbs1 protein in control of general response to defect in tRNA biosynthesis in yeast Saccharomyces cerevisiae
Project leader: Prof. dr hab. Magdalena Rakowska-Boguta
Duration: 2018-01-10 / 2022-01-09
Budget: 957 600 PLN
Title: Thermodynamics of halogen bonding in the bio-molecular cage
Project leader: Prof. dr hab. Jarosław Poznański
Duration: 2018-01-15 / 2022-10-14
Budget: 1 398 000 PLN
Title: Analysis of selected processes influencing the architecture of fungal genomes and proteomes
Project leader: Dr hab. Anna Muszewska
Duration: 2018-01-19 / 2022-01-18
Budget: 403 840 PLN
Title: The role of ALKBH proteins in obesity and type 2 diabetes development using the pig model
Project leader: Prof. dr hab. Elżbieta Grzesiuk
Duration: 2019-01-19 / 2022-01-17
Budget: 1 240 920 PLN
Title: Quantitative assessment of sediment transport from glaciers of South Shetland Islands on the basis of selected remote sensing methods
Project leader: Dr hab. Robert Bialik
Duration: 2018-07-02 / 2022-07-01
Budget: 898 400 PLN
Title: Variability of Antarctic lichen microbiome in a trophic and a spatio-temporal gradient (King George Island, South Shetland Islands)
Project leader: Dr Jakub Grzesiak
Duration: 2018-05-21 / 2022-05-20
Budget: 817 020 PLN
Title: Apoptotic machinery: An ancient adaptation to aerobic conditions?
Project leader: Dr hab. Szymon Kaczanowski
Duration: 2018-06-29 / 2022-12-28
Budget: 786 200 PLN
Title: SnRK2 protein kinases as integrators of environmental signals in the regulation of the senescence in plants
Project leader: Dr Anna Marta Kulik
Duration: 2018-10-31 / 2022-10-30
Budget: 1 552 100 PLN
Title: Isolation of resistance genes to PVY infection, usefull in potato (Solanum tuberosum L) breading and its functional analysis
Project leader: Prof. dr hab. Jacek Hennig
Duration: 2018-07-20 / 2022-07-19
Budget: 1 457 500 PLN
Title: Clonal analysis of Streptococcus pyogenes strains resistant to macrolide antibiotics
Project leader: Dr Izabela Kern-Zdanowicz
Duration: 2018-08-14 / 2021-08-13
Budget: 1 027 302 PLN
Title: Integrating light and osmotic stress signaling- molecular functions of Plastid Movement Impaired 1 protein from Arabidopsis thaliana
Project leader: Mgr Olga Sztatelman
Duration: 2019-01-14 / 2023-01-13
Budget: 1 242 600 PLN
Title: Dolichol – a superlipid essential for the functioning of the eukaryotic cell
Project leader: Prof. dr hab. Ewa Kula-Świeżewska
Duration: 2019-01-14 / 2023-01-13
Budget: 1 997 400 PLN
Title: The role and cooperation of AidB dehydrogenase and AlkB dioxygenase in repair of adducts to DNA and RNA bases
Project leader: Dr hab. Agnieszka Maciejewska
Duration: 2019-01-09 / 2023-01-08
Budget: 924 400 PLN
Title: Analysis of functional interdependence between organ-specific choice of alternative transcription start site (altTSS) and SWI/SNF dependent chromatin remodeling in Arabidopsis
Project leader: Dr Szymon Kubala
Duration: 2019-01-14 / 2023-01-13
Budget: 1 618 800 PLN
Title: Novel molecular mechanisms in extracellular copper transport
Project leader: Prof. dr hab. Wojciech Bal
Duration: 2019-01-15 / 2023-01-14
Budget: 1 522 000 PLN
Title: Characterization of genetic determinants of propionic acid biosynthesis and assessing of their functionality in selected lactic acid bacteria
Project leader: Dr hab. Tamara Aleksandrzak-Piekarczyk
Duration: 2019-01-09 / 2023-01-08
Budget: 623 000 PLN
Title: Topology of Pseudomonas aeruginosa chromosome. The role of partitioning protein ParB
Project leader: Prof. d hab. Grażyna Jagura-Burdzy
Duration: 2019-02-15 / 2023-02-14
Budget: 2 100 800 PLN
Title: A proteomic approach to define interactors of Zika Virus with the host cell nucleolus
Project leader: Prof. dr hab. Michał Dadlez
Duration: 2019-01-24 / 2023-01-23
Budget: 1 072 126 PLN
Title: Regulation of cell death and OXPHOS activity by Fmp40 ampylase in yeast S. cerevisiae
Project leader: Dr hab. Róża Kucharczyk
Duration: 2019-06-13 / 2022-06-12
Budget: 1 671 600 PLN
Title: The role of HopAG1 effector in virulence of plant pathogenic bacteria
Project leader: Dr Magdalena Górecka
Duration: 2019-06-18 / 2022-06-17
Budget: 1 021 800 PLN
Title: Design of photoswitchable dismantlers of biomaterials made of amyloid fibrils
Project leader: Dr Dorota Niedziałek
Duration: 2019-06-18 / 2022-06-17
Budget: 618 600 PLN
Tytuł projektu: Uncovering novel secondary seed dormancy regulators in Arabidopsis
Project leader: Dr Ruslan Yatusewich
Duration: 2019-06-18 / 2022-06-17
Budget: 1 456 400 PLN
Title: Characterisation of function and substrate binding of the prefoldin chaperone in physiology and cellular stress
Project leader: Dr Ulrike Topf
Duration: 2019-10-01 / 2022-09-30
Budget: 1 882 500 PLN
Title: Identification of Streptococcus aninosus virulence factors
Project leader: Dr hab. Izabela Kern-Zdanowicz
Duration: 2019-09-02 / 2022-09-01
Budget: 1 005 620 PLN
Title: Modification and action of non-coding RNA
Project leader: Dr Jacek Nowak
Duration: 2020-02-05 / 2023-02-04
Budget: 2 063 140 PLN
Title: Functional genomic analysis of Staphylococcus aureus Kayvirus genus phages in a search for molecular basis of wide host-range and the strategies of survival with a host population
Project leader: Dr hab. Małgorzata Barbara Łobocka
Duration: 2020-02-06 / 2023-02-05
Budget: 2 249 194 PLN
Title: New aspects of negative regulation of RNA polymerase III in yeast Saccharomyces cerevisiae
Project leader: Dr Małgorzata Maria Cieśla
Duration: 2020-09-01 / 2023-08-31
Budget: 1 252 200 PLN
Title: Identification and comprehensive classification of peptidases
Project leader: Dr Kamil Steczkiewicz
Duration: 2020-06-25 / 2023-06-24
Budget: 878 400 PLN
Title: Novel mechanisms regulating the activity of cis-prenyltransferases in plants
Project leader: Dr hab. Liliana Surmacz
Duration: 2020-10-02 / 2024-10-01
Budget: 1 969 800 PLN
Title: In solution or in the membrane? Determination of partition of beta-amyloid peptides between the water and phospholipid phase and its small molecular effectors
Project leader: Prof. dr hab. Wojciech Bal
Duration: 2021-01-19 / 2024-01-18
Budget: 2 269 200 PLN
Title: Novel aspects of virulence mechanisms of HopBF1, a bacterial effector that targets host HSP90 protein
Project leader: Dr hab. Magdalena Krzymowska
Duration: 2021-03-15 / 2025-03-14
Budget: 2 131 200 PLN
Title: Assessing protein-ligand complexes with ML/DL models trained on molecular dynamics-based descriptors
Project leader: Dr hab. Paweł Aleksander Siedlecki
Duration: 2021-07-16 / 2024-07-15
Budget: 517 280 PLN
Title: Identification of the interdependence between SWI/SNF-type chromatin remodeling complex, metabolism control and RNA modification in salivary gland cystic carcinoma as a basis for a new targeted therapy
Project leader: Dr hab. Tomasz Jacek Sarnowski
Duration: 2021-07-23 / 2025-07-22
Budget: 2 532 720 PLN
Title: Interferon-inducible anti-bacterial immunity factors of the host cell cytosol
Project leader: Dr Michał Piotr Wandel
Duration: 2021-09-01 / 2025-08-31
Budget: 2 586 000 PLN
Title: LCRPlatform: new algorithms and methods for the comprehensive identification, categorization, and annotation of protein low complexity regions
Project leader: Dr hab. Marcin Maciej Grynberg
Duration: 2021-03-15 / 2025-03-14
Budget: 464 820 PLN
Title: The role of alternative EF-G’s in translation regulation during antibiotic biosynthesis in Myxococcus xanthus
Project leader: Dr hab. Agata Lucyna Starosta
Duration: 2021-10-29 / 2025-10-28
Budget: 3 513 000 PLN
Title: Ancestral traits and genomic innovations in early diverging fungi – implications for mucormycosis
Project leader: Dr hab. inż. Anna Muszewska
Duration: 2022-03-01 /
Budget: 1 348 588 PLN
Title: Molecular basis of neurodegenerative diseases – the influence of selected metallic nanoparticles
Project leader: Prof. dr hab. Maciej Leszek Kozak / Dr Igor Żukow
Duration: 2021-12-23 / 2025-12-22
Budget: 366 000 PLN
Title: Impact of Lactococcus and Leuconostoc bacteria on reinforcing gut barrier – from identification of potentially probiotic strains and molecular factors involved in muco-affinity to evaluation of their mucus protective function in vivo
Project leader: Dr hab. Magdalena Kowalczyk
Duration: 2022-03-01 /
Budget: 1 558 126 PLN
Title: Mechanisms regulating the cellular level of the most mutagenic human DNA polymerase – the role of p300 acetyltransferase and hypoxia
Project leader: Dr hab. Justyna McIntyre
Duration: 2022-01-12 / 2026-01-11
Budget: 1 763 200 PLN
Title: Posttranscriptional reshaping of mRNA pool in seeds
Project leader: Dr Michał Adam Krzysztoń
Duration: 2022-03-01 /
Budget: 1 817 800 PLN
Title: Expanding the mitochondrial proteome via the non-canonical translation mechanisms
Project leader: Prof. dr hab. Joanna Kufel/ Dr hab. Roman Szczęsny
Duration: 2022-09-01 /
Budget: 1 596 000 PLN

PRELUDIUM

Title: The role of the Cdc45 protein in the maintenance of genomic stability in yeast Saccharomyces cerevisiae
Project leader: Mgr Milena Denkiewicz-Kruk
Duration: 2017-06-02 / 2023-03-01
Budget: 150 000 PLN
Title: Identification of nuclear function of Arabidopsis Target of Rapamycin protein
Project leader: Mgr Paweł Ćwiek
Duration: 2018-01-25 / 2021-01-24
Budget: 180 000 PLN
Title: Characterization of genetic determinants of the mannose-specific phosphotransferase system (Man-PTS) determining sensitivity to the newly identified subclass IId bacteriocins
Project leader: Mgr Aleksandra Tymoszewska
Duration: 2019-01-09 / 2022-08-08
Budget: 139 800 PLN
Title: Evaluation of the function of the SNF5-type core sibunit of the SWI/SNF complex on Arabidopsis thaliana using new T-DNA insertionan knock-out line
Project leader: Mgr Jarosław Steciuk
Duration: 2019-01-15 / 2023-01-14
Budget: 210 000 PLN
Title: The PA2504 protein – a novel player in regulation of exotoxin A production of Pseudomonas aeruginosa?
Project leader: Mgr Joanna Drabińska
Duration: 2019-01-24 / 2022-01-23
Budget: 138 720 PLN
Title: Biology and systematics of Antarctic polar lactic acid bacteria strains of the genus Carnobacterium in the light of phenotypic and genetic analyses
Project leader: Mgr inż. Katarzyna Kosiorek
Duration: 2019-06-21 / 2022-06-20
Budget: 139 980 PLN
Title: Identification of group I SnRK2s substrates involved in RNA metabolism and elucidation the role of their phosphorylation
Project leader: Mgr Adrian Kasztelan
Duration: 2020-02-28 / 2023-02-27
Budget: 210 000 PLN
Title: Moonlighting role of yeast WASP (Las17) in the nucleolus: possible implications for Wiskott-Aldrich syndrome etiology
Project leader: Mgr Justyna Antoniuk-Majchrzak
Duration: 2020-02-05 / 2023-02-04
Budget: 203 544 PLN
Title: Analysis of Escherichia coli ydiU mutation suppressors and detergent resistant membrane fraction as a way to discover functional relationships of family SelO AMPylases involved in oxidative stress response from bacteria to humans
Project leader: Mgr Monika Karasiewicz-Urbańska
Duration: 2020-06-15 / 2022-06-14
Budget: 139 656 PLN
Title: Analysis of bacteriophage P1 lytic functions as a way to discover the mechanisms of wide dissemination of clinical bacterial strains carrying P1 derivatives with genes encoding resistance to new generation beta-lactam antibiotics
Project leader: Mgr Agnieszka Bednarek
Duration: 2020-06-25 / 2023-06-24
Budget: 139 920 PLN
Title: Differential activity of ribonucleotide repair on leading and lagging DNA strand and its consequences for the mechanism and fidelity of replication of both DNA strands in Escherichia coli cells
Project leader: Mgr Krystian Łazowski
Duration: 2020-07-28 / 2022-07-27
Budget: 139 920 PLN
Title: The role of NBR1 and the LSU (RESPONSE TO LOW SULFUR) proteins in stability of Arabidopsis thaliana catalases
Project leader: Mgr inż. Anna Niemiro
Duration: 2022-01-12 / 2023-01-11
Budget: 69 540 PLN

PRELUDIUM BIS

Title: High-resolution analysis of data from proton-deuterium exchange experiments monitored by mass spectrometry
Project leader: Prof. dr hab. Michał Dadlez
Duration: 2020-10-01 / 2024-09-30
Budget: 519 600 PLN

SONATA

Title: Rab-dependent vesicular transport and sterol homeostasis- where is the link?
Project leader: Dr Małgorzata Gutkowska-Stronkowska
Duration: 2017.02.07 / 2021-02-06
Budget: 432 800 PLN
Title: Mechanisms of polyprenol biosynthesis regulation at transcriptional level
Project leader: Dr Daniel Buszewicz
Duration: 2018-04-20 / 2021-04-19
Budget: 990 000 PLN
Title: Comprehensive study of the role of Rysto, a TIR-NB-LRR class receptor in potato innate immunity
Project leader: Dr Marta Grech-Baran
Duration: 2020-06-25 / 2023-06-24
Budget: 909 000 PLN
Title: Molecular mechanisms driving formation of muscular exophers and their role in proteostasis and life cycle of C. elegans
Project leader: Dr Michał Turek
Duration: 2020-11-05 / 2023-11-04
Budget: 1 896 240 PLN
Title: Molecular mechanisms linking RNA polymerase III mutations to Hypomyelinating leukodystrophy (HLD)
Project leader: Dr Tomasz Wojciech Turowski
Duration: 2021-07-16 / 2024-07-15
Budget: 1 535 600 PLN
Title: Nowy mechanizm kontroli ekspresji genów u Eukaryota poprzez regulację długości ogonów poliadenozynowych kodujących transkryptów
Project leader: Dr Agnieszka Irena Tudek
Duration: 2021-10-01 / 2024-09-30
Budget: 1 642 400 PLN

SONATA BIS

Title: Dissection of putative transcriptional regulators from Pseudomonas aeruginosa proteome dependent on ParA/ParB using systems biology tools
Project leader: Dr hab. Aneta Bartosik
Duration: 2016.04.20 / 2022-04-19
Budget: 1 518 680 PLN
Title: Analysis of the human SKI complex, a central player in cytoplasmic RNA decay and surveillance pathways
Project leader: Dr hab. Rafał Tomecki
Duration: 2018-05-08 / 2023-05-07
Budget: 2 643 200 PLN
Title: Bet-hedging in plants – multi level analysis of seed dormancy variability – from singel cell to population
Project leader: Dr hab. Szymon Świeżewski
Duration: 2019-06-13 / 2024-06-12
Budget: 3 711 000 PLN
Title: How does ribosome heterogeneity contribute to cellular stress defense?
Project leader: Dr Ulrike Topf
Duration: 2020-10-01 / 2025-09-30
Budget: 3 861 212 zł

SONATINA

Title: Polyhydroxyacids of psychrophilic polar region bacteria: role in bacterial adaptation to stress conditions and biotechnological potential
Project leader: Dr Jakub Grzesiak
Duration: 2017-10-10 / 2022-04-09
Budget: 647 116 PLN
Title: Transport pathway for non-coding RNA during meiosis
Project leader: Dr Julita Gruchota
Duration: 2019-09-12 / 2022-09-11
Budget: 999 465 PLN

SHENG

Title: Dissecting DNA Maintenance Methylation in Mammals: Fidelity, Timing and Instructive Cues
Project leader: Prof. dr hab. Matthias Bochtler
Duration: 2019-10-02 / 2023-10-01
Budget: 1 737 600 PLN

BEETHOVEN LIFE

Title: Dissection of the signaling function of O-acetylserine in plants
Project leader: Prof. dr hab. Agnieszka Ewa Sirko
Duration: 2020-01-29 / 2023-01-28
Budget: 1 472 600 PLN

THE POLISH NATIONAL AGENCY FOR ACADEMIC EXCHANGE

INTERNATIONAL COOPERATION AND EXCHANGE

Title: Mass spectrometry imaging of single seeds in relation with seed physiological quality
Project leader: Dr hab. Szymon Świeżewski
Duration:
Budget: 25 000 PLN

POLISH RETURNS

Title: Identification and characterisation of novel anti-bacterial restriction factors Project leader: Dr Michał Wandel
Duration: 2021-09-01 / 2025-09-01
Budget: 1 780 000 PLN
Title: Functional framework for viral RNA-dependent RNA polymerase, a major target in COVID19 treatment
Project leader: dr Tomasz Turowski
Duration: 2021-08-01 / 2025-07-31
Budget: 1 760 000 PLN

WELCOME

Title: Welcome to IBB
Project leader: Dr hab Roman Szczęsny
Duration: 2021-06-01 / 2023-05-31
Budget: 316 260 PLN

NATIONAL CENTRE FOR RESEARCH AND DEVELOPMENT

Title: Application of novel diagnostic and therapeutical methods in epilepsy and neurodevelopmental abnormalities in children based on the clinical and cellular model of mTOR dependent epilepsy
Project leader: Prof. dr hab. Michał Dadlez
Duration: 2017-04-01 / 2021-09-30
Budget: 3 928 980 zł

MEDICAL RESEARCH AGENCY

Title: Development of novel mRNA/VLP-based vaccines against emerging zoonotic viral diseases
Project leader: Dr hab. Roman Szczęsny
Duration: 2021-10-29/ 2023-12-14
Budget: 858 326 PLN

EMBO

Title: Translation regulation in bacteria – Specialized ribosomes in Bacillus subtilis.
Project leader: Dr hab. Agata Starosta
Duration: 2021-04-01 / 2022-12-31
Budget: 639 425 PLN
Title: Intracellular mechanisms of anti-microbial immunity
Project leader: Dr Michał Wandel
Okres realizacji: 2021-09-01 / 2024-08-30
Budget: 705 000 PLN

HORIZON

MCSA – European Postdoctoral Fellowships

Title: Population-wide analysis of molecular and metabolic features intrinsic to dormancy variability in single seeds — POP1Seed
Project leader: Dr Julia Zinsmeister
Duration: 2021-10-01 / 2024-09-30
Budget: 623 788 PLN